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The principal cytochrome P450 isoenzyme associated appears being CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. Around 85% of an oral dose seems during the urine inside 24 several hours of administration, most as the glucuronide conjugate, with modest amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity details.Bas